Mechanical Unloading Promotes Myocardial Energy Recovery in Human Heart Failure Running title : Gupte et al ; Metabolism in human heart failure
نویسندگان
چکیده
Methodist Diabetes and Metabolism Institute; Department of Systems Medicine and Bioengineering, Center for Biostatistics, Houston Methodist Research Institute, Houston, TX & Weill Cornell Medical College, New York, NY; Department of Medicine, Department of Radiology, Houston Methodist Hospital, Houston, TX & Weill Cornell Medical College, New York, NY; Methodist DeBakey Heart and Vascular Institute, Houston, TX & Weill Cornell Medical College, New York, NY; Sarah W. Stedman Nutrition and Metabolism Center, and Departments of Pharmacology and Cancer Biology and Medicine, Duke University Medical Center; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY; Catedra de Cardiologia, Instituto Tecnologico de Monterrey, Monterrey, Mexico; The University of Texas Medical School at Houston, Houston, TX *contributed equally
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Letter to the Editor: "Evaluate the effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina"
Dear editor In a recent issue of the journal, Dastani et al. (2019) evaluate the effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina. Despite the fact that the topic was interesting, there were some defects and we wish to call to your attention important factual issues in this publication. The most cr...
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متن کاملMechanical unloading promotes myocardial energy recovery in human heart failure.
BACKGROUND Impaired bioenergetics is a prominent feature of the failing heart, but the underlying metabolic perturbations are poorly understood. METHODS AND RESULTS We compared metabolomic, gene transcript, and protein data from 6 paired samples of failing human left ventricular tissue obtained during left ventricular assist device insertion (heart failure samples) and at heart transplant (po...
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n this issue of the Journal, Patten et al. (1) report the mpact of unloading therapy in humans with advanced tage D heart failure who were supported with a left entricular-assist device (VAD). The authors hypotheized that the hemodynamic improvements that accomany VAD support would decrease the expression of yocardial inducible nitric oxide synthase (iNOS) and ardiomyocyte apoptosis in failing ...
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Even after incomplete myocardial recovery during mechanical circulatory support, long-term survival rates after ventricular assist device (VAD) explantation can be better than those expected after heart transplantation even for patients with chronic non-ischemic cardiomyopathy as the underlying cause for VAD implantation. The elective therapeutic use of ventricular assist devices for heart fail...
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